Wat you are completely right, there is no way to know there is not ever just one of something in nature, but I was using my intuition when I made that statement. If there is any proof of it in what we see all around us, all I can say is that something that occurs one time, should at least theoretically, be able to happen more than once. I dont see why our universe or us for that matter should be so special. So I guess it's also the anthropogenic argument. In some ways it reminds me of the intelligent life on other worlds (or life on other worlds at all) argument. Ironic you mentioned agnosticism! I'm agnostic too, but as far as religion is concerned, I find the idea of polytheism far more likely than monotheism. "Gods" would just be a substitute for extremely advanced intelligent species that can create universes haha.
Sean Carroll in the statement above seems to come to the conclusion that having multiple universes preserves symmetries like the arrow of time.
I like Poplawski's too, when you think about it, the universe can be defined as the inside of a black hole for the simple reason we can never leave it! Could you imagine that the reason why singularities exist is for the simple reason is that they each contain a different universe with different dimensions therefore they cannot be described by the physics of our universe?