I run both Manjaro linux and linux Mint on my computer (i7-4790S, 16Gb ram, RX580) and I've ran into trouble. Whenever I lauched SE, it crashed within seconds.
With some testing, I was able to find the problem (sort of) : SE is not working with Mesa 20.3.X nor the 21 developpement version from github but it is working perfectly fine with 20.2.X. I tried forcing specific OpenGL versions through steam launch options and change settings in main-user.cfg but that didn't help. Looking at se.log, I saw I crashed just before [MT] Physical VRAM: ..., so I think my problem might be linked to the changes made in 20.3 to some VRAM related things (I'm not entirely sure, but I think Mesa 20.3 is the first version able to "fake" the amout of VRAM actually available).
In the meantime, SE is still playable but I'm worried because I can't stay on 20.2.X forever.
If anyone has an idea, that would help me very much ! If not, I'll submit a bug report to Mesa.
Here is the error I get from Wine/Proton, and I also linked my se.log pastebin :
"wine: Unhandled page fault on execute access to 0000000000000000 at address
0000000000000000 (thread 00d8), starting debugger..."
Have a good day and happy new year !