https://www.hsph.harvard.edu/news/?post ... 1354834848
https://www.hsph.harvard.edu/news/?post ... 1354834886
http://www.cnn.com/2017/08/22/health/li ... index.html
https://www.hsph.harvard.edu/news/press ... st-cancer/
https://www.hsph.harvard.edu/news/press ... st-cancer/
Boston, MA – Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School of Public Health. The link was stronger among women who worked night shifts.
The study will be published online August 17, 2017 in Environmental Health Perspectives.
“In our modern industrialized society, artificial lighting is nearly ubiquitous. Our results suggest that this widespread exposure to outdoor lights during nighttime hours could represent a novel risk factor for breast cancer,” said lead author Peter James, assistant professor at Harvard Medical School’s Department of Population Medicine at Harvard Pilgrim Health Care Institute, who did the work while a research fellow in the Departments of Epidemiology and Environmental Health at Harvard Chan School.
Previous studies have suggested that exposure to light at night may lead to decreased levels of the hormone melatonin, which can disrupt circadian rhythms—our internal “clocks” that govern sleepiness and alertness—and, in turn, lead to increased breast cancer risk.
The new study, the most comprehensive to date to examine possible links between outdoor light at night and breast cancer, looked at data from nearly 110,000 women enrolled in the Nurses’ Health Study II from 1989-2013. The researchers linked data from satellite images of Earth taken at nighttime to residential addresses for each study participant, and also considered the influence of night shift work. The study also factored in detailed information on a variety of health and socioeconomic factors among participants.
Women exposed to the highest levels of outdoor light at night—those in the top fifth—had an estimated 14% increased risk of breast cancer during the study period, as compared with women in the bottom fifth of exposure, the researchers found. As levels of outdoor light at night increased, so did breast cancer rates.
https://www.hsph.harvard.edu/news/multi ... vironment/
The sources of pollution in these countries are varied—from coal-burning power plants to emissions from industrial agricultural—such as the fumes of livestock waste and nitrogen-rich fertilizers.
And we’re already starting to see some of the consequences of environmental degradation.
https://www.hsph.harvard.edu/news/?post ... 1354835036
https://www.hsph.harvard.edu/news/?post ... 1354834975
https://www.hsph.harvard.edu/news/topic ... al-health/
https://www.hsph.harvard.edu/news/hsph- ... chemicals/
https://www.nap.edu/catalog/24758/appli ... -chemicals
A new report outlines a strategy to improve the ability of regulators at the U.S. Environmental Protection Agency (EPA) to evaluate whether certain chemicals might cause hormone-related health effects at low doses. The strategy is aimed at supplementing existing EPA toxicity testing, which the authors say can miss harms from exposure to endocrine active chemicals (EACs) in small concentrations.
The report, by the U.S. Environmental Protection Agency’s Committee on Endocrine-Related Low-Dose Toxicity, was released on July 18, 2017. Russ Hauser, Frederick Lee Hisaw Professor of Reproductive Physiology at Harvard T.H. Chan School of Public Health, is a member.
Exposure to EACs can have lasting and significant health effects, particularly during embryonic development. For this report, the committee reviewed data around two types of EACs: phthalates (found in a range of products including toys and cosmetics) and PBDEs (used as flame retardants). They found that exposure in utero to DEHP–a type of phthalate used as a plasticizer–was linked to declines in male reproductive hormones, and that exposure to PDBEs may affect intelligence.
According to the researchers, more information is needed on the movement of chemicals within the body to better evaluate an EAC’s potential to cause health effects in humans at low doses.
Recommendations by Hauser and his co-authors include increased surveillance of a variety of data sources for signs that a chemical may be affecting health, systematic reviews of evidence around any such signal, and updating chemical assessments.
A new report outlines a strategy to improve the ability of regulators at the U.S. Environmental Protection Agency (EPA) to evaluate whether certain chemicals might cause hormone-related health effects at low doses. The strategy is aimed at supplementing existing EPA toxicity testing, which the authors say can miss harms from exposure to endocrine active chemicals (EACs) in small concentrations.
The report, by the U.S. Environmental Protection Agency’s Committee on Endocrine-Related Low-Dose Toxicity, was released on July 18, 2017. Russ Hauser, Frederick Lee Hisaw Professor of Reproductive Physiology at Harvard T.H. Chan School of Public Health, is a member.
Exposure to EACs can have lasting and significant health effects, particularly during embryonic development. For this report, the committee reviewed data around two types of EACs: phthalates (found in a range of products including toys and cosmetics) and PBDEs (used as flame retardants). They found that exposure in utero to DEHP–a type of phthalate used as a plasticizer–was linked to declines in male reproductive hormones, and that exposure to PDBEs may affect intelligence.
According to the researchers, more information is needed on the movement of chemicals within the body to better evaluate an EAC’s potential to cause health effects in humans at low doses.
Recommendations by Hauser and his co-authors include increased surveillance of a variety of data sources for signs that a chemical may be affecting health, systematic reviews of evidence around any such signal, and updating chemical assessments.
A new report outlines a strategy to improve the ability of regulators at the U.S. Environmental Protection Agency (EPA) to evaluate whether certain chemicals might cause hormone-related health effects at low doses. The strategy is aimed at supplementing existing EPA toxicity testing, which the authors say can miss harms from exposure to endocrine active chemicals (EACs) in small concentrations.
The report, by the U.S. Environmental Protection Agency’s Committee on Endocrine-Related Low-Dose Toxicity, was released on July 18, 2017. Russ Hauser, Frederick Lee Hisaw Professor of Reproductive Physiology at Harvard T.H. Chan School of Public Health, is a member.
Exposure to EACs can have lasting and significant health effects, particularly during embryonic development. For this report, the committee reviewed data around two types of EACs: phthalates (found in a range of products including toys and cosmetics) and PBDEs (used as flame retardants). They found that exposure in utero to DEHP–a type of phthalate used as a plasticizer–was linked to declines in male reproductive hormones, and that exposure to PDBEs may affect intelligence.
According to the researchers, more information is needed on the movement of chemicals within the body to better evaluate an EAC’s potential to cause health effects in humans at low doses.
Recommendations by Hauser and his co-authors include increased surveillance of a variety of data sources for signs that a chemical may be affecting health, systematic reviews of evidence around any such signal, and updating chemical assessments.
A new report outlines a strategy to improve the ability of regulators at the U.S. Environmental Protection Agency (EPA) to evaluate whether certain chemicals might cause hormone-related health effects at low doses. The strategy is aimed at supplementing existing EPA toxicity testing, which the authors say can miss harms from exposure to endocrine active chemicals (EACs) in small concentrations.
The report, by the U.S. Environmental Protection Agency’s Committee on Endocrine-Related Low-Dose Toxicity, was released on July 18, 2017. Russ Hauser, Frederick Lee Hisaw Professor of Reproductive Physiology at Harvard T.H. Chan School of Public Health, is a member.
Exposure to EACs can have lasting and significant health effects, particularly during embryonic development. For this report, the committee reviewed data around two types of EACs: phthalates (found in a range of products including toys and cosmetics) and PBDEs (used as flame retardants). They found that exposure in utero to DEHP–a type of phthalate used as a plasticizer–was linked to declines in male reproductive hormones, and that exposure to PDBEs may affect intelligence.
According to the researchers, more information is needed on the movement of chemicals within the body to better evaluate an EAC’s potential to cause health effects in humans at low doses.
Recommendations by Hauser and his co-authors include increased surveillance of a variety of data sources for signs that a chemical may be affecting health, systematic reviews of evidence around any such signal, and updating chemical assessments.
https://www.hsph.harvard.edu/news/hsph- ... ed-cities/
https://www.hsph.harvard.edu/news/topic ... al-health/
https://www.hsph.harvard.edu/news/press ... eficiency/
https://www.hsph.harvard.edu/news/multi ... vironment/
https://www.hsph.harvard.edu/news/hsph- ... chemicals/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002207/
Several studies over the last decade have suggested that the modern practice of keeping our bodies exposed to artificial light at night, or LAN, increases cancer risk, especially for cancers (such as breast and prostate cancers) that require hormones to grow. Women who work night shifts have shown higher rates of breast cancer,1 whereas blind women, who are not likely to be exposed to or perceive LAN, have shown decreased risks.2 In 2007, the International Agency for Cancer Research declared shiftwork a probable human carcinogen.3 Now a large study of 164 countries adds another piece of evidence, implicating overall light pollution.
https://www.ncbi.nlm.nih.gov/pubmed/9637858
https://www.ncbi.nlm.nih.gov/pubmed/17867390
https://www.ncbi.nlm.nih.gov/pubmed/20962033
https://www.ncbi.nlm.nih.gov/pubmed/18232528
https://www.ncbi.nlm.nih.gov/pubmed/9628967
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558066/
http://cescos.fau.edu/observatory/light ... state.html
http://cescos.fau.edu/observatory/light ... inzanoMaps
http://cescos.fau.edu/observatory/light ... n_Spectrum
http://cescos.fau.edu/observatory/lightpol-BrCa.html
https://www.ncbi.nlm.nih.gov/pubmed/9628967
https://www.ncbi.nlm.nih.gov/pubmed/18232528
https://www.ncbi.nlm.nih.gov/pubmed/20962033
https://www.ncbi.nlm.nih.gov/pubmed/17867390
https://www.ncbi.nlm.nih.gov/pubmed/9637858
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558066/
https://www.ncbi.nlm.nih.gov/pmc/articl ... 7/citedby/
https://www.ncbi.nlm.nih.gov/sites/entr ... dbfrom=pmc
https://www.ncbi.nlm.nih.gov/sites/entr ... dbfrom=pmc
http://cescos.fau.edu/observatory/light ... c_Patterns
http://cescos.fau.edu/observatory/light ... and_breast cancer
http://cescos.fau.edu/observatory/lightpol-BrCa.html
harvard study light pollution breast cancer
The science in a nutshell: Researchers are concerned that certain health problems can be caused by a long term decrease in the naturally and nightly occurring hormone melatonin, which is only secreted when it is dark and which regulates our sleep/wake cycles and other hormonal glands. While there are different factors that can prevent melatonin from being made by the pineal gland under our brains, such as its calcification due to old age, this web page has been following the particular factor of light pollution at night. Researchers are finding that exposure to bright nocturnal light decreases the human body's production of melatonin, A decrease in melatonin production has been linked to higher rates of breast cancer in women and higher rates of prostate cancer in men. A bit more details on these steps follows.
Light prevents the production of melatonin through primitive ganglion eye cells in our retinas, which we have recently learned are photosensitive. These photosensitive ganglion eye cells are active at or have a peak sensitivity to particular blue wavelengths which does not match the same peak sensitivities of the retinal rod or cone cells. Rod and cone cells are the same retinal cells which you may remember learning about in biology class. While certain cones and rods can see this same spectral region, they just don't react to it as strongly as the ganglion cells do. So blue light, just like blue daytime skies, triggers these ganglion cells, and that makes blue light is our zietgeber (time-giver). These cells send this information to our brain's suprachiasmatic nuclei (SCN), which is a collection of brain cells that is the center of our biological clocks or our circadian system. The SCN turns off the pineal gland, a small endocrine organ that lies just under our brains. However, when it is dark, the ganglion cells do not detect blue light, so the SCN lets the pineal gland produce its hormone melatonin. This melatonin is the chemical message that is released to our body in the blood which causes/activates certain health inducing activities.
Once in the blood, melatonin can not only suppress cancer cell growth or even cause cancer cell death, it also reaches other hormone producing glands, such as the ovaries in women and the pituitary gland, and stops the production of their hormones. The hormones that come from these glands in women are estrogen, progesterone, follicle stimulating hormone (F.S.H.), and the luteinizing hormone (L.H.), can cause rapid breast tissue cell growth. It is the cellular growth and turnover can can allow errors to occur in their genetic coding, which can lead to cancer. Ever greater growth and turnover means more frequent chances for coding errors, and so, greater chances of cancer.
Also, melatonin has been found to absorb a free radicals, such as hydroxyl ( OH ) , ionized oxygen molecule ( O2- ), and nitric oxide ( NO ). Free radicals are generated by ionizing radiation and are is estimated to cause almost 70% of biological damage to DNA, proteins, and cellular membranes, the hydroxyl radical most especially. While there are antioxidants that can clean these oxidized radicals up, many of them do not do so permanently. They can release the radical and recapture it and release it and ... (called redox cycling) back into the body to cause damage again, for example vitamin C. However, melatonin, once oxidized by such a radical, terminally breaks apart, but does not release the radical. Its pieces apparently can also consume more free radical, in fact, a single melatonin molecule can consume up to ten free radical molecule species!
Background: So why be concerned with these cancers, especially breast cancer? Well, after skin cancer, breast cancer is the most common cancer among women in the US, and it is the second leading cause of cancer death in women, after lung cancer. Those issues are better covered in our Light Pollution and Breast Cancer pages. How it affects men and their prostates is still being worked out.
The problem is that even weak amounts of light impedes our pineal gland from creating the beneficial melatonin. Without melatonin, other glands produce hormones unchecked, which lead to greater cancer rates. In our industrialized societies, light pollution or light at nights becomes harder and harder to avoid, even if you knew to avoid it. Everyone's impression is that it is only light. And this apathetic acceptance may be a reason for the ever greater breast cancer rates in industrialized societies. Technology is only good when it is properly used. So while we may herald modern and super-lit technological society, when it threatens our health, it needs to be called into question, even if it is just light.
Summary: Does light pollution directly cause cancer? No. Unlike in astronomy, light itself is not the problem.
It is our biological reactions to the light that is the problem.
So, the next time that someone says to you but it's just light, tell them: no, light is our biological triggering input that suppresses a cascade of subtle, health improving functions that should naturally and nightly occur in our bodies. These functions include those that promote better sleep, fight depression, fight obesity, and consume free radicals which damage DNA and cells and negate some risk factors for certain cancers. It is NOT just light.
Because more of us are sleeping in overly lit nights, light pollution has been found to be a missing, aggravating factor that suppresses melatonin levels in humans at night. This change pulls out the stops to cancer cell growth. The hormone melatonin normally suppresses cancer cell growth and can even cause cancer cell death. In women, it does this by inhibiting the sex ovaries from growing too fast and from releasing hormones can cause breast tissue cells to multiply faster. This would increase the chance that they become cancerous. The papers mentioned below examine this effect in detail. Once you are done here, you may want to head over to our Prevent Light Pollution page to find steps you can take to end this problem to yourself and others.
The papers that have been reviewed are reorganized by subject and by date in this listing. I have commented on them in a chronological sequence below.
Lights at night, melatonin levels and prostate cancer in men:
Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study
Global Co-Distribution of Light at Night (LAN) and Cancers of Prostate, Colon, and Lung in Men.
Melatonin May Lower Prostate Cancer Risk
Back to Light Pollution vs. Human Health
How Society's Light Pollution affects Human Breast Cancer
Background: The pages on this website have been concerned with light pollution. So why be concerned with cancer, especially breast cancer? Well, after skin cancer, breast cancer is the most common cancer among women in the US, and it is the second leading cause of cancer death in women, after lung cancer. The following data came from the American Cancer Society's Breast Cancer Facts & Figures publications.
Year: 2005 2007 2 2009 2011 2013
New cases of invasive breast cancer 211,240 178,480 192,370 230,480 232,340
New cases of CIS 1 58,490 62,030 62,280 57,650 64,640
Deaths 40,410 40,460 40,170 39,520 39,620
1 CIS (carcinoma in situ) is non-invasive and is the earliest form of breast cancer.
2 The expected number of new breast cancers in 2007 was markedly lower than the estimate for 2005 in the previous Breast Cancer Facts & Figures report due to the use of a new, more accurate estimation method and a small decline in the breast cancer incidence rate.
American Cancer Society. Breast Cancer Facts & Figures 2005-2006. Breast Cancer Facts & Figures 2007-2008. Breast Cancer Facts & Figures 2009-2010. Breast Cancer Facts & Figures 2011-2012. Atlanta: American Cancer Society, Inc.
According to the ACS's Cancer Facts & Figures reports, the death rate of the breast cancer is going down. This is attributed to the continual messages about getting check out, finding the cancers earlier, and to better treatments.
However, it does not say that the numbers of new cases are going down.
Note that one technique to fighting cancer is to use hormone suppressant therapies. For some types of breast cancer, about two out of three cases are said to be hormone sensitive, for they are fueled by the hormones estrogen or progesterone. Biopsies can reveal whether a tumor has receptors for estrogen (ER-positive) and/or progesterone (PR-positive). And there are medications that keep the hormones from promoting further cancer growth. However, instead of society sitting around and wait for a pill to be one day invented that will cure breast cancer, it seems to me that we should take action to avoid causing it in the first place by making changes that allow our own natural suppressant abilities to work. Prevention that we can do is an intelligent first action to take before cancer occurs.
The problem is that even weak amounts of light can impede our pineal gland from creating the beneficial melatonin. Without melatonin, other glands produce their hormones unchecked, which lead to ever greater breast cancer rates. In our industrialized societies, light pollution or light at nights becomes harder and harder to avoid, even if you knew to avoid it. Everyone's impression is that it is only light. And this apathetic acceptance may be a reason for the ever greater breast cancer rates in industrialized societies. Technology is only good when it is properly used. So while we may herald a modern, glitzy, flashy and hyper-lit technological society, when it threatens our health, it needs to be called into question, even if it is just light.
The papers that have been reviewed are reorganized by subject and by date in this listing. I have commented on them in a chronological sequence below.
Lights at night and breast cancer risks in women
Geographic Patterns of Breast Cancer in the U.S.
Electric Power Use and Breast Cancer: A Hypothesis
Inverse association between breast cancer incidence and degree of visual impairment in Finland
Night Shift Work, Light at Night, and Risk of Breast Cancer
Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study
Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
Light at Night Co-distributes with Incident Breast but not Lung Cancer in the Female Population of Israel.
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Does the Modern Urbanized Sleeping Habitat Pose a Breast Cancer Risk?
Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer